|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Our findings suggest that in Klf4-null cells, decreased Bnip3 expression impairs mitophagy and is associated with increased mitochondrial ROS production after mitochondrial damage, providing a rationale for their genomic instability and supports a tumor suppressive role for KLF4 in certain tumors as previously observed.
|
31839365 |
2020 |
|
Hyperglycemia
|
0.020 |
Biomarker
|
disease |
BEFREE |
Acute hyperglycemia increased Bnip3 and Beclin-1 expressions after ischemia-reperfusion in young and middle-aged rats but not in old rats, whereas it increased the expression of Bax, cytochrome c, Atg5, and LC3B-II only in young or middle-aged rats.
|
30596897 |
2020 |
|
Anxiety
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Considering the advantages attributed to pentylenetetrazole (PTZ)-induced kindling mouse model, we used the model for the following assessments: 1. to observe changes in cognition and anxiety between wild type (WT) mice and TRPM2-KO mice with the recognition of new things trial and elevated plus-maze; 2. to determine the expression of apoptosis-associated proteins (PARP1, BNIP3, AIF, and Endo G) using Reverse transcription-polymerase chain reaction (RT-PCR) and Western blot; 3. to observe neurons pathologic damages and astrocyte activation in each group.
|
31794795 |
2020 |
|
Anxiety Disorders
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Considering the advantages attributed to pentylenetetrazole (PTZ)-induced kindling mouse model, we used the model for the following assessments: 1. to observe changes in cognition and anxiety between wild type (WT) mice and TRPM2-KO mice with the recognition of new things trial and elevated plus-maze; 2. to determine the expression of apoptosis-associated proteins (PARP1, BNIP3, AIF, and Endo G) using Reverse transcription-polymerase chain reaction (RT-PCR) and Western blot; 3. to observe neurons pathologic damages and astrocyte activation in each group.
|
31794795 |
2020 |
|
Epilepsy
|
0.010 |
Biomarker
|
disease |
BEFREE |
The transient receptor potential melastatin type 2 channel (TRPM2) is a Ca<sup>2+</sup>-permeable cation channel that contributes to cell apoptosis; its possible signaling pathway is the PARP1/BNIP3/AIF/Endo G pathway that may be related to epilepsy.
|
31794795 |
2020 |
|
Heart failure
|
0.230 |
Biomarker
|
disease |
BEFREE |
The FOXO3a (forkhead box O3a)-BNIP3 (B-cell lymphoma 2/adenovirus E1B 19kDa interacting protein 3) pathway modulates mitochondrial dynamics and function and contributes to myocardial remodeling in rodent models of heart failure.
|
30744415 |
2019 |
|
Congestive heart failure
|
0.230 |
Biomarker
|
disease |
BEFREE |
The FOXO3a (forkhead box O3a)-BNIP3 (B-cell lymphoma 2/adenovirus E1B 19kDa interacting protein 3) pathway modulates mitochondrial dynamics and function and contributes to myocardial remodeling in rodent models of heart failure.
|
30744415 |
2019 |
|
Myocardial Infarction
|
0.210 |
Biomarker
|
disease |
BEFREE |
Thus, the purpose of this study was to test the hypothesis that miR-105 participates in the regulation of RIP3/p-MLKL- and BNIP3-dependent necroptosis/apoptosis in H9c2 cells and MI rat hearts.
|
30743213 |
2019 |
|
Retinal Detachment
|
0.210 |
Biomarker
|
disease |
BEFREE |
Our previous study demonstrated the protective effect on detached retina by BNIP3-mediated autophagy.
|
31072291 |
2019 |
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
p53/BNIP3-dependent mitophagy limits glycolytic shift in radioresistant cancer.
|
30664690 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
BNIP3 dramatically alleviated FTO-dependent tumor growth retardation and metastasis.
|
30922314 |
2019 |
|
Primary malignant neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
p53/BNIP3-dependent mitophagy limits glycolytic shift in radioresistant cancer.
|
30664690 |
2019 |
|
Breast Carcinoma
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
BNIP3 acts as a tumor suppressor and is negatively correlated with FTO expression in clinical breast cancer patients.
|
30922314 |
2019 |
|
Malignant neoplasm of breast
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
BNIP3 acts as a tumor suppressor and is negatively correlated with FTO expression in clinical breast cancer patients.
|
30922314 |
2019 |
|
Neoplasm Metastasis
|
0.080 |
Biomarker
|
phenotype |
BEFREE |
For this reason, it is noted that the targeting of the BNIP3 may be useful in preventing the rapid growth and metastasis of residual HCC after IRFA.[BMB Reports 2019; 52(4): 277-282].
|
30940322 |
2019 |
|
Neoplasm Metastasis
|
0.080 |
Biomarker
|
phenotype |
BEFREE |
BNIP3 dramatically alleviated FTO-dependent tumor growth retardation and metastasis.
|
30922314 |
2019 |
|
Liver carcinoma
|
0.070 |
Biomarker
|
disease |
BEFREE |
For this reason, it is noted that the targeting of the BNIP3 may be useful in preventing the rapid growth and metastasis of residual HCC after IRFA.[BMB Reports 2019; 52(4): 277-282].
|
30940322 |
2019 |
|
Liver carcinoma
|
0.070 |
PosttranslationalModification
|
disease |
BEFREE |
Altogether, our results highlight the involvement of HIFs overexpression and BNIP3 methylation-dependent knockdown in the development of sorafenib resistance in HCC.
|
31835431 |
2019 |
|
melanoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
Hence, BNIP3 is a vital component of the mitochondria quality control required for glutamine-driven melanoma aggressiveness.
|
29924728 |
2019 |
|
B-Cell Lymphomas
|
0.040 |
Biomarker
|
group |
BEFREE |
The FOXO3a (forkhead box O3a)-BNIP3 (B-cell lymphoma 2/adenovirus E1B 19kDa interacting protein 3) pathway modulates mitochondrial dynamics and function and contributes to myocardial remodeling in rodent models of heart failure.
|
30744415 |
2019 |
|
Renal Cell Carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
In the present study, our hypothesis was that BNIP3, a gene positioned downstream of HIF, would be expressed at a higher level in ccRCC; however, instead, lower levels of BNIP3 expression were identified in RCC tumor tissues compared with adjacent non‑tumor tissues.
|
30365137 |
2019 |
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
In the present study, our hypothesis was that BNIP3, a gene positioned downstream of HIF, would be expressed at a higher level in ccRCC; however, instead, lower levels of BNIP3 expression were identified in RCC tumor tissues compared with adjacent non‑tumor tissues.
|
30365137 |
2019 |
|
Mammary Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
RNA N6-methyladenosine demethylase FTO promotes breast tumor progression through inhibiting BNIP3.
|
30922314 |
2019 |
|
Alzheimer's Disease
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
In this study, for the first time, we present, by means of a quantitative PCR protocol with reverse transcriptase, the expression of BECN1 and CASP3 genes in the neuronal CA3 region of the hippocampus with the co-expression of the mitochondrial BNIP3 gene, which genes are associated with Alzheimer's disease, in the ischemic model of Alzheimer's disease in the rat.
|
31707369 |
2019 |
|
Hyperglycemia
|
0.020 |
Biomarker
|
disease |
BEFREE |
Thus, the results of this study suggest that BDNF/TrkB/HIF-1α/BNIP3-mediated mitophagy protects BMECs from hyperglycemia.
|
30877409 |
2019 |